Aesthetic Anxiety in a Child with Cleidocranial Dysplasia

porky pig face Cleidocranial dysplasia (CCD) is a rare syndrome that affects the skeleton and teeth.It is characterized by absent or hypoplastic clavicles, mobile shoulder girdles, patent fontanelles, supernumerary teeth, retained deciduous and delayed permanent teeth.A 10 year old boy with CCD is reported with chief complaints of aesthetics and de

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A unified analysis of evolutionary and population constraint in protein domains highlights structural features and pathogenic sites

Abstract Protein evolution is constrained by structure and function, creating cactus tiki mug patterns in residue conservation that are routinely exploited to predict structure and other features.Similar constraints should affect variation across individuals, but it is only with the growth of human population sequencing that this has been tested at

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